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  • Title: How are specialized (low-fidelity) eukaryotic polymerases selected and switched with high-fidelity polymerases during translesion DNA synthesis?
    Author: Fischhaber PL, Friedberg EC.
    Journal: DNA Repair (Amst); 2005 Feb 03; 4(2):279-83. PubMed ID: 15590336.
    Abstract:
    Specialized DNA polymerases are required in both prokaryotic and eukaryotic cells for bypassing sites of template DNA damage that arrest high-fidelity DNA replication. Recent studies in the literature provide hints of the complexity of DNA switching between polymerases for translesion DNA synthesis (TLS) and those for normal DNA replication.
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