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  • Title: Growth factor receptor expression in orbital lymphangioma: possible therapeutic implications.
    Author: Esmaeli B, Prieto VG, Gonnering R, Hawes MJ, Diba R, Saadati HG, Shepler TR, Karcioglu Z.
    Journal: Orbit; 2004 Dec; 23(4):263-9. PubMed ID: 15590529.
    Abstract:
    OBJECTIVE: To examine the expression of molecules targeted by imatinib mesylate (STI571;Gleevec) and epidermal growth factor receptor (EGFR) inhibitors in orbital lymphangiomas. DESIGN: Retrospective observational case series. PARTICIPANTS: Six patients with orbital lymphangioma treated at four institutions between March 2000 and December 2002. METHODS: Tissue specimens and medical records from six patients were collected. Immunohistochemical analysis was performed using antibodies against c-kit and platelet-derived growth factor receptor (PDGFR) alpha and beta and EGFR tyrosine kinase.
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