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  • Title: Targeting malaria virulence and remodeling proteins to the host erythrocyte.
    Author: Marti M, Good RT, Rug M, Knuepfer E, Cowman AF.
    Journal: Science; 2004 Dec 10; 306(5703):1930-3. PubMed ID: 15591202.
    Abstract:
    To establish infection in the host, malaria parasites export remodeling and virulence proteins into the erythrocyte. These proteins can traverse a series of membranes, including the parasite membrane, the parasitophorous vacuole membrane, and the erythrocyte membrane. We show that a conserved pentameric sequence plays a central role in protein export into the host cell and predict the exported proteome in Plasmodium falciparum. We identified 400 putative erythrocyte-targeted proteins corresponding to approximately 8% of all predicted genes, with 225 virulence proteins and a further 160 proteins likely to be involved in remodeling of the host erythrocyte. The conservation of this signal across Plasmodium species has implications for the development of new antimalarials.
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