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  • Title: A new immunosuppressant, FTY720, in canine kidney transplantation: effect of single-drug, induction and combination treatments.
    Author: Suzuki T, Jin MB, Shimamura T, Yamashita K, Taniguchi M, Nomura M, Yokota R, Fukai M, Magata S, Horiuchi H, Fujita M, Nagashima K, Furukawa H, Todo S.
    Journal: Transpl Int; 2004 Nov; 17(10):574-84. PubMed ID: 15592714.
    Abstract:
    Three different types of treatment were conducted to clarify the properties of a novel immunomodulator, FTY720, in canine kidney allograft models. Survival, biochemical and hematological tests, pharmacokinetics, and histopathology of grafts and extra-renal organs were analyzed. Accompanying a remarkable reduction in circulating lymphocytes, single-drug treatment of FTY720, ranging from 0.05 to 10 mg/kg, exhibited significant prolongation of graft survival without a dose-dependent effect. Short-course induction with FTY720 at 5 mg/kg per day exhibited similar anti-rejection effects as did single-drug treatment but no advantage in rescuing ongoing rejection. In combination with cyclosporine (CsA; 5 mg/kg) or tacrolimus (FK; 0.5 mg/kg), FTY720 had an additive effect. Trough blood concentrations of FTY720 were linearly correlated with dose. No animal showed critical adverse effects at any point. FTY720 holds promise as a candidate in a new category of drugs that can be combined with conventional agents for induction and maintenance immunosuppression in clinical organ transplantation.
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