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  • Title: Electrical stimulation with a needle-type electrode inserted into the optic nerve in rabbit eyes.
    Author: Sakaguchi H, Fujikado T, Kanda H, Osanai M, Fang X, Nakauchi K, Ikuno Y, Kamei M, Ohji M, Yagi T, Tano Y.
    Journal: Jpn J Ophthalmol; 2004; 48(6):552-7. PubMed ID: 15592779.
    Abstract:
    PURPOSE: To investigate whether electrical stimulation of the optic nerve can elicit an electrical evoked potential (EEP) in rabbits and to determine whether such stimulation is a useful approach for the placement of a visual prosthesis. METHODS: Two needle-type electrodes were inserted into the optic nerve using a transvitreal approach. For electrical stimulation, monophasic and biphasic pulses were used. By stimulating the optic nerve, the EEP was elicited. After evaluation of the EEP, a histological study was carried out. RESULTS: When electrical stimulation was applied, the EEP could be recorded. The threshold with monophasic and biphasic stimulation was 10 +/- 0 microA and 20 +/- 8.2 microA, respectively. Histological examination revealed no major complications, such as bleeding or degeneration, which might have resulted from the insertion of electrodes or the electrical stimulation. CONCLUSIONS: Electrical stimulation of the optic nerve can elicit an EEP, suggesting that this approach may be useful for a visual prosthesis system.
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