These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Genetic analysis of innate immunity: TIR adapter proteins in innate and adaptive immune responses.
    Author: Beutler B, Hoebe K, Georgel P, Tabeta K, Du X.
    Journal: Microbes Infect; 2004 Dec; 6(15):1374-81. PubMed ID: 15596123.
    Abstract:
    The innate immune system senses pathogens largely through signals initiated by a collection of phylogenetically related proteins known as "Toll-like receptors" (TLRs), of which 10 representatives are encoded in the human genome. Our understanding of the sensing role played by the TLRs began with the positional cloning of a spontaneous mutation (Lps(d)) in the gene encoding the mammalian lipopolysaccharide (LPS) receptor. Other key innate immunity proteins have been disclosed by germline mutagenesis, and are discussed in the present review.
    [Abstract] [Full Text] [Related] [New Search]