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  • Title: [Treatment of acid-related diseases of the gastrointestinal tract. Observations in patients receiving a single evening dose of 300 mg ranitidine].
    Author: Sewing KF, Franz E.
    Journal: Fortschr Med; 1992 Mar 10; 110(7):114-6. PubMed ID: 1559647.
    Abstract:
    UNLABELLED: Testing of the effectiveness and tolerability of ranitidine treatment in acid-related diseases of the gastrointestinal tract in non-selected outpatients. STUDY DESIGN: Observations made by 15,180 general practitioners and internists in the Länder of former West Germany in the period January 1989 to December 1990. PATIENTS: 23,783 patients with acid-related diseases of the gastrointestinal tract for which treatment with ranitidine is indicated (no further diagnostic or therapeutic requirement). TREATMENT: 300 mg ranitidine administered in the form of a single evening dose. RESULTS: A duodenal ulcer presented in 50.1%, a gastric ulcer in 26%, and reflux esophagitis in 29.6% of the patients; in 17.5% some other gastrointestinal disease (for the most part gastritis) was diagnosed. Six weeks of treatment was associated with a high rate of healing (more than 90%). The total incidence of side effects was a very low 0.77% (183 cases). These results confirm the effectiveness and good tolerability of ranitidine.
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