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  • Title: The results of CO2 laser surgery in patients with oral leukoplakia: a 25 year follow up.
    Author: van der Hem PS, Nauta JM, van der Wal JE, Roodenburg JL.
    Journal: Oral Oncol; 2005 Jan; 41(1):31-7. PubMed ID: 15598583.
    Abstract:
    Oral leukoplakia is an important premalignant lesion of the oral mucosa. We treat this lesion prophylactically with CO2 laser evaporation. In the period from 1976 to 2001, a group of 200 patients with 282 oral leukoplakias were treated by CO2 laser evaporation. In a follow up period of 1-219 months (mean 52), 251 treated leukoplakias (89.0%) did not show a recurrence. Twenty eight (9.9%) local recurrences were observed in 5 to 168 months after treatment. Three (1.1%) squamous cell carcinoma, occurred in the treated area respectively 7, 17 and 19 month after CO2 laser evaporation. This large study with a long follow up shows that laser treatment is a good prophylactic treatment for oral leukoplakia.
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