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  • Title: Exacerbation of protracted-relapsing experimental allergic encephalomyelitis in DA rats by gluten-free diet.
    Author: Di Marco R, Mangano K, Quattrocchi C, Amato F, Nicoletti F, Buschard K.
    Journal: APMIS; 2004 Oct; 112(10):651-5. PubMed ID: 15601316.
    Abstract:
    The observation of neurological dysfunctions resembling multiple sclerosis (MS) seen clinically and/or by MRI in patients with celiac disease has focused attention on the possibility that cryptic gluten sensitivity may be involved in the pathogenesis of MS. Here we study the effects of a gluten-free diet on the course of protracted-relapsing EAE in DA rats, serving as a preclinical model of human MS. The data show not only that this nutritional approach failed to ameliorate development of the disease but rather that it exacerbated the course.
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