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  • Title: Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist.
    Author: Nakajima Y, Hamashima H, Washizuka K, Tomishima Y, Ohtake H, Imamura E, Miura T, Kayakiri H, Kato M.
    Journal: Bioorg Med Chem Lett; 2005 Jan 17; 15(2):251-4. PubMed ID: 15603933.
    Abstract:
    The discovery of a novel, potent and selective beta(3)-adrenergic receptor (AR) agonist is described. SAR studies demonstrated the structural requirements for activity and selectivity. Compound 1c, which showed good beta(3)-AR activity and selectivity, was identified and pharmacokinetics were investigated.
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