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  • Title: Schizophyllan-folate conjugate as a new non-cytotoxic and cancer-targeted antisense carrier.
    Author: Hasegawa T, Fujisawa T, Haraguchi S, Numata M, Karinaga R, Kimura T, Okumura S, Sakurai K, Shinkai S.
    Journal: Bioorg Med Chem Lett; 2005 Jan 17; 15(2):327-30. PubMed ID: 15603948.
    Abstract:
    Schizophyllan having folate-appendages was synthesized from native schizophyllan through NaIO(4)-oxidation and the subsequent reductive amination in aqueous ammonia followed by amido-coupling with folic acid. The resulting folate-appended schizophyllan can form stable complex with poly(dA), show specific affinity toward folate binding protein, and mediate effective antisense activity in cancer cells.
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