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  • Title: A novel series of potent gamma-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core.
    Author: Lewis SJ, Smith AL, Neduvelil JG, Stevenson GI, Lindon MJ, Jones AB, Shearman MS, Beher D, Clarke E, Best JD, Peachey JE, Harrison T, Castro JL.
    Journal: Bioorg Med Chem Lett; 2005 Jan 17; 15(2):373-8. PubMed ID: 15603957.
    Abstract:
    A new series of gamma-secretase inhibitors was developed from an in-house screening hit based on a benzobicyclo[4.2.1]nonane core. Lead optimisation studies led to the development of a series of potent inhibitors and in vivo efficacy was demonstrated.
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