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  • Title: Docking dinucleotides to HIV-1 integrase carboxyl-terminal domain to find possible DNA binding sites.
    Author: Zhu HM, Chen WZ, Wang CX.
    Journal: Bioorg Med Chem Lett; 2005 Jan 17; 15(2):475-7. PubMed ID: 15603976.
    Abstract:
    HIV-1 integrase mediates a processed viral DNA into the host genome DNA. The binding modes between HIV-1 integrase and viral/host DNA have not been clarified until now. The C-terminal domain of integrase has been found to be a DNA-binding domain. In this work, we have explored the possible DNA binding sites of dimeric C-terminal domain by docking dinucleotides to HIV-1 integrase. The docking results suggest that two symmetrical DNA-binding sites are likely located on the outside surface of the dimeric C-terminal domain and not located in the groove. Those sites are in agreement with the experimental data.
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