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  • Title: Partial protection induced by a BHV-1 recombinant vaccine against challenge with BHV-5.
    Author: Spilki FR, Silva AD, Hübner S, Esteves PA, Franco AC, Driemeier D, Roehe PM.
    Journal: Ann N Y Acad Sci; 2004 Oct; 1026():247-50. PubMed ID: 15604501.
    Abstract:
    Bovine herpesvirus type 5 (BHV-5) is the causative agent of bovine herpetic encephalitis, a major concern for cattle farming in Brazil and Argentina. We recently developed a differential, gE-negative vaccine (265 gE-), based on a Brazilian BHV-1 strain. The present study was carried out to examine whether such a vaccine would confer protection to BHV-5 infections. It was concluded that the recombinant BHV-1 vaccine tested here is not capable of conferring full protection to BHV-5 challenge.
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