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  • Title: [The factors of disease-free survival in patients with nodal metastases of cutaneous melanoma].
    Author: Mikhnin AE, Barchuk AS.
    Journal: Vopr Onkol; 2004; 50(4):426-9. PubMed ID: 15605765.
    Abstract:
    The time between primary lesion excision to lymphadenectomy for cutaneous melanoma was determined in 550 patients. Maximum relapse-free interval was 17.8 years, mean--16.4 months, with median time of 6.2 months. We used retrospective multivariate analysis of the time for metastases to the regional lymph nodes with such variables as sex, age at tumor presentation, site, volume of tumor or largest nodular metastasis, number of involved nodes, satellites, Breslow thickness, ulceration, epithelioid-cell presence, pigmentation, mitotic index, spontaneous tumor regression, invasive growth (Clark), and lymphoid infiltration. A retrospective univariate analysis involved such significant predictors as spontaneous tumor regression (p(0.00001), logarithm of primary tumor volume (p=0.0005), sex (p=0.0007), tumor site (p=0.008), satellites (p=0.011), and Clark's index (p=0.025). Cox's multivariate analysis established a relationship between relapse-free time and such variablesas spontaneous tumor regression (p(0.00001), logarithm of primary tumor volume (p=0.0006), tumor site (p=0.016), logarithm of volume of largest nodular metastasis (p=0.019), and sex (p=0.032).
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