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  • Title: [Effect of high dose-fentanyl on cerebrospinal fluid pressure in patients with normal intracranial pressure under halothane anesthesia].
    Author: Shimizu H, Mayumi T, Matsumiya N, Fujita S.
    Journal: Masui; 1992 Mar; 41(3):376-80. PubMed ID: 1560577.
    Abstract:
    The effect of high dose fentanyl on cerebrospinal fluid pressure (CSFP) was studied in 16 consented patients scheduled for major surgery with thoracotomy. In all patients, CSFP was measured through a 23G spinal needle at L3/L4 intervertebral space on the lateral position under light halothane-nitrous oxide-oxygen anesthesia (halothane 0.2-0.3%). After the control values were taken fentanyl, 50 micrograms.kg-1 (n = 8) or 100 micrograms.kg-1 (n = 8) was administered intravenously in 15 min. After the administration of both doses of fentanyl, CSFP decreased but not significantly. Mean blood pressure and cerebral perfusion pressure (CPP) decreased significantly within 5 min after the beginning of fentanyl administration but CPP did not decrease below 50 mmHg in any cases. These results indicate that high dose fentanyl has little influence on intracranial pressure in normal patients and could be used safely for neuroanesthesia.
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