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  • Title: [Effect of external ionizing radiation on morphofunctional indices of the hypothalamus, hypophysis and adrenal glands].
    Author: Derev'ianko LP, Nosov AT.
    Journal: Lik Sprava; 2004; (5-6):64-8. PubMed ID: 15605826.
    Abstract:
    The laboratory rats exposed to one-time external ionizing radiation have been found to have phase changes of morphofunctional and secretory cells activity of hypothalamus, hypophysis, cortex and medullary of adrenal glands. The first phase called reactive (3-7 days) is characterized by enhancing energy-producing, protein-synthesizing and secretory functions of secretory sells of hypothalamus supraoptic nucleus, corticotrophic cells of adenohypophysis, adrenocorticytes of cortex and adrenocytes of medullary of adrenal glands. The second phase of dystrophic changes (7-14) is characterized by different degree of distrophic-destructive changes. The third phase (14-1 month) is characterized by compensatory adaptative and recovery processes during which we can see on the background of dystrophic changes the processes of intracellular reparative regeneration. The fourth phase (1-3 months) is characterized by virtually complete recovery of morphofunctional and secretory activity of most cells of hypothalamus, hypophysis and adrenal glands.
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