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  • Title: One-pot sequential Cu-catalyzed reduction and Pd-catalyzed arylation of silyl enol ethers.
    Author: Chae J, Yun J, Buchwald SL.
    Journal: Org Lett; 2004 Dec 23; 6(26):4809-12. PubMed ID: 15606072.
    Abstract:
    [reaction: see text] Enantiomerically enriched beta-substituted diphenylsilyl enol ethers, which can be prepared from Cu-catalyzed asymmetric conjugate reduction, are utilized in the Pd-catalyzed arylation of various aryl bromides. This new method provides a simple route to alpha-arylated cycloalkanones with excellent levels of enantiomeric and diastereomeric purity. The isolation of the intermediate, diphenylsilyl enol ethers is not necessary; the procedure can be carried out in one-pot.
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