These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Design and synthesis of a bimodal target-specific contrast agent for angiogenesis.
    Author: Dirksen A, Langereis S, de Waal BF, van Genderen MH, Meijer EW, de Lussanet QG, Hackeng TM.
    Journal: Org Lett; 2004 Dec 23; 6(26):4857-60. PubMed ID: 15606084.
    Abstract:
    [structure: see text] A bimodal target-specific contrast agent based on a cyclic peptide containing the target-specific NGR sequence, gadolinium(III) diethylenetriaminepentaacetic acid (Gd(III)DTPA), and Oregon Green 488 (OG488) suitable for both MR imaging and optical imaging of angiogenesis is developed. The synthetic strategy for this target-specific contrast agent exploits the use of highly efficient, chemoselective reactions, such as native chemical ligation, and gives a straightforward approach for double labeling of peptides in general.
    [Abstract] [Full Text] [Related] [New Search]