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  • Title: Catalytic enantioselective alkynylation of prochiral sp3 C-H bonds adjacent to a nitrogen atom.
    Author: Li Z, Li CJ.
    Journal: Org Lett; 2004 Dec 23; 6(26):4997-9. PubMed ID: 15606119.
    Abstract:
    [reaction: see text] The construction of chiral carbon centers via the first catalytic asymmetric alkynylation of prochiral CH2 groups was developed by using a copper-catalyzed double activation of sp3 and sp C-H bonds. Optically active 1-alkynylated tetrahydroisoquinolines were obtained by this method.
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