These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synergic in-vitro activity of imipenem and sulbactam against Acinetobacter baumannii.
    Author: Choi JY, Park YS, Cho CH, Park YS, Shin SY, Song YG, Yong D, Lee K, Kim JM.
    Journal: Clin Microbiol Infect; 2004 Dec; 10(12):1098-101. PubMed ID: 15606639.
    Abstract:
    The interaction between sulbactam and imipenem was evaluated with four clinical isolates of Acinetobacter baumannii, including two isolates resistant to imipenem, one of which produced IMP-1 metallo-beta-lactamase. Two isolates (one of which was imipenem-resistant) were sulbactam-resistant by undefined mechanisms. MICs were determined by standard broth microdilution methods. Time-kill assays with imipenem and sulbactam, alone or in combination at 0.5 x MIC and 1 x MIC, showed a synergic effect in all four isolates of A. baumannii after incubation for 0, 4, 8 and > 24 h at 35 degrees C.
    [Abstract] [Full Text] [Related] [New Search]