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  • Title: Reduced pulmonary endothelium-bound angiotensin converting enzyme activity in diabetic rabbits.
    Author: McCloud LL, Parkerson JB, Zou L, Rao RN, Catravas JD.
    Journal: Vascul Pharmacol; 2004; 41(4-5):159-65. PubMed ID: 15607499.
    Abstract:
    We examined the effects of diabetes on pulmonary capillary endothelial cell (EC) function in diabetic rabbits. One, three and six weeks after alloxan treatment, rabbits were anesthetized and pulmonary endothelium-bound angiotensin converting enzyme (ACE) activity was estimated from the single-pass transpulmonary hydrolysis of benzoyl-Phe-Ala-Pro (BPAP), an ACE specific substrate. ACE activity significantly decreased in 1- and 3-week diabetic rabbits and returned to control levels at 6 weeks. Capillary dilation, parenchymal hemorrhage and erythrocyte clumping were maximal in 3-week diabetic rabbits. We conclude that in the alloxan-diabetic rabbit, there are transient functional and more persistent morphological alterations.
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