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  • Title: Early failure of a tricuspid valve replacement with a mitral valve homograft in a heart transplant recipient.
    Author: Alharethi R, Shaddy RE, Doty DB, Moore SA, Hammond ME, Dabbas B, Fuller TC, Renlund DG.
    Journal: J Heart Lung Transplant; 2004 Dec; 23(12):1460-2. PubMed ID: 15607681.
    Abstract:
    A 24-year-old woman experienced severe tricuspid valve regurgitation 6 years after heart transplantation. Tricuspid valve replacement was performed using a cryopreserved mitral valve homograft. Severe tricuspid valve regurgitation recurred within 4 months, associated with an increase in the panel reactive antibody titers from zero to 72%. Tricuspid valve replacement was repeated with a porcine bioprosthesis with excellent recovery and function for >2 years. The mitral valve homograft displayed inflammatory features consistent with humoral immune-mediated destruction.
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