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  • Title: Expression of chitin synthase genes during yeast and hyphal growth phases of Candida albicans.
    Author: Chen-Wu JL, Zwicker J, Bowen AR, Robbins PW.
    Journal: Mol Microbiol; 1992 Feb; 6(4):497-502. PubMed ID: 1560778.
    Abstract:
    Chitin, the beta 1,4-linked polymer of N-acetylglucosamine, is a fibrous polysaccharide that in many yeasts helps to maintain the structure of the mother-bud junction and in filamentous fungi is often the major supporting component of the cell wall. We have previously described a Candida albicans chitin synthase, CHS1. The DNA and derived protein sequences of a second gene, CHS2, are presented and compared with previously published gene sequences. Northern blot analysis shows that strikingly different levels of synthase 1 and 2 expression occur during yeast and hyphal phases of Candida growth.
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