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  • Title: [The assessment of perinatal brain damage in premature infants at risk by serial creatine kinase BB measurements].
    Author: Amato M, Jäggi I, Hüppi P.
    Journal: Padiatr Padol; 1992; 27(1):17-20. PubMed ID: 1560991.
    Abstract:
    Peri-intraventricular bleeding (PIVH) is considered the most common cause of neurologic damage or death in low birthweight infants (less than 1000 g birth weight and 31 weeks of gestation). High-resolution real-time ultrasound scan is used for early diagnosis of PIVH in neonates. Furthermore, increase of serum creatine-kinase BB (CK-BB) values has been found to be clinically useful for diagnosis and prognosis of several perinatal cerebrovascular injuries. Eighty-eight preterm infants with different grades of PIVH (I-IV) were studied by serial measurements of CK-BB levels in serum. No statistical correlation was found between enzymatic levels and severity of PIVH (p greater than 0.5).
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