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  • Title: A new structural theme in the imidazole-containing alkaloids from a calcareous Leucetta sponge.
    Author: Ralifo P, Crews P.
    Journal: J Org Chem; 2004 Dec 24; 69(26):9025-9. PubMed ID: 15609934.
    Abstract:
    Further study of the Fijian sponge Leucetta sp., a source of (+)-calcaridine A (4) and (-)-spirocalcaridines A (5) and B (6), has yielded (-)-spiroleucettadine (8), the first natural product to contain a fused 2-aminoimidazole oxalane ring along with the known compounds N,N-dimethylnaamidine D (3) and isonaamine B (7). NMR analysis allowed the unambiguous 2D structural assignment of 8, and its relative stereochemistry was determined by ROESY data. Good antibacterial activity was observed for 8 against Enterococcus durans with an MIC of less than 6.25 microg/mL.
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