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  • Title: Integration from proteins to organs: the IUPS Physiome Project.
    Author: Hunter P, Smith N, Fernandez J, Tawhai M.
    Journal: Mech Ageing Dev; 2005 Jan; 126(1):187-92. PubMed ID: 15610778.
    Abstract:
    The IUPS Physiome Project is an internationally collaborative open source project intended to provide a public domain framework for computational physiology, including the development of modeling standards, computational tools and web-accessible databases of models of structure and function at all spatial scales and across all organ systems. Here, we illustrate the application of this multi-scale modeling approach to three organ systems: the heart, the lungs and the musculo-skeletal system, and in each case we show how the organ level models incorporate tissue and cell-level physiology. Although the computational physiology framework presented here does not yet incorporate models of ageing processes, the model-based approach is certainly capable of describing ageing and disease-related processes both via parameter changes within the models of normal physiological processes and via models of additional processes added to the framework.
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