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  • Title: Identification of the K efflux channel coupled to the gastric H-K-ATPase during acid secretion.
    Author: Lambrecht NW, Yakubov I, Scott D, Sachs G.
    Journal: Physiol Genomics; 2005 Mar 21; 21(1):81-91. PubMed ID: 15613615.
    Abstract:
    Genomic microarray analysis of genes specifically expressed in a pure cell isolate from a heterocellular organ identified the likely K efflux channel associated with the gastric H-K-ATPase. The function of this channel is to supply K to the luminal surface of the pump to allow H for K exchange. KCNQ1-KCNE2 was the most highly expressed and significantly enriched member of the large variety of K channels expressed in the gastric epithelium. The function of this K channel in acid secretion was then shown by inhibition of secretion in isolated gastric glands with specific KCNQ inhibitors and by colocalization of the channel with the H-K-ATPase in the secretory canaliculus of the parietal cell. KCNQ1-KCNE2 appears to be the K efflux channel that is essential for gastric acid secretion.
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