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  • Title: The V-ATPase inhibitors concanamycin A and bafilomycin A lead to Golgi swelling in tobacco BY-2 cells.
    Author: Robinson DG, Albrecht S, Moriysu Y.
    Journal: Protoplasma; 2004 Dec; 224(3-4):255-60. PubMed ID: 15614486.
    Abstract:
    Concanamycin A and bafilomycin A are well-known inhibitors of V-ATPase activity. It is known that they interfere with intracellular protein trafficking in both animal and plant cells, but a cellular target for their action in plant cells has not been defined. Here we show that treatment with these inhibitors leads to a massive vacuolation of the Golgi apparatus. The effect is similar, but not identical, to that previously described for the Na+/K+ ionophores and is reversible after washing.
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