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  • Title: Burn-induced gastric mucosal hemodynamic disturbance in the rat. Role of platelet-activating factor.
    Author: Binnaka T, Yamaguchi T, Kubota Y, Fujimura K, Tani K, Kitagawa S, Mizuno T, Inoue K.
    Journal: Scand J Gastroenterol; 1992; 27(2):89-92. PubMed ID: 1561532.
    Abstract:
    The role of platelet-activating factor (PAF) as a mediator of gastric damage associated with burn injury was examined in the rat. Gastric mucosal hemodynamics was recorded continuously by means of laser-Doppler flowmetry and reflectance spectrophotometry. Burn injury induced prolonged hypotension and rapid-onset and long-lasting gastric mucosal hemodynamic derangement-that is, ischemia with congestion. This hemodynamic disturbance was significantly inhibited by CV-6209, a specific PAF antagonist. Elevated tissue levels of thiobarbituric acid reactants and pathologic changes in the gastric mucosa subsequent to burn injury were also significantly alleviated by the preadministration of CV-6209. These results strongly suggest a role of PAF as an important mediator of gastric damage after burn injury through its potent vasoactive effect on gastric microcirculation.
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