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  • Title: Streptococcus pyogenes pharyngeal isolates with reduced susceptibility to ciprofloxacin in Spain: mechanisms of resistance and clonal diversity.
    Author: Albertí S, Cortés G, García-Rey C, Rubio C, Baquero F, García-Rodríguez JA, Bouza E, Aguilar L.
    Journal: Antimicrob Agents Chemother; 2005 Jan; 49(1):418-20. PubMed ID: 15616324.
    Abstract:
    A survey of emm gene sequences and an analysis of the pulsed-field electrophoretic profiles of 30 Streptococcus pyogenes isolates with reduced susceptibilities to ciprofloxacin detected the prevalence of isolates with emm type 6 and considerable genetic diversity among isolates. The mechanism of ciprofloxacin resistance in these isolates was based on point mutations in topoisomerase IV subunit C encoded by parC, mainly replacement of serine-79 by alanine.
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