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  • Title: In vivo resistance of a laboratory-selected Aspergillus fumigatus isolate to amphotericin B.
    Author: Manavathu EK, Cutright JL, Chandrasekar PH.
    Journal: Antimicrob Agents Chemother; 2005 Jan; 49(1):428-30. PubMed ID: 15616327.
    Abstract:
    The fungal burdens (number of CFU per pair of lungs) in mice infected with Aspergillus fumigatus AB16.4 (for which the amphotericin B [AMB] MIC was elevated) and W73355 (drug-susceptible parent) were reduced by 21 and 81%, respectively, after 5 days of AMB treatment (2 mg/kg/day), indicating that AB16.4 also shows reduced susceptibility to AMB in a murine pulmonary aspergillosis model.
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