These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Protective effect of ligustrazine on insulin resistance after local cerebral ischemia of rat].
    Author: Wang YJ, Jiang AH, Wang QM, Bai M, Ma KL.
    Journal: Zhongguo Zhong Yao Za Zhi; 2003 Dec; 28(12):1181-3. PubMed ID: 15617507.
    Abstract:
    OBJECTIVE: To study the protective effect of Ligustrazine on IR after local cerebral ischemia of rat. METHOD: Models of rat IR after local cerebral ischemia were prepared by electrocagulation of the middle cerebral artery, and changes of serum insulin, tomer necrosis factor-alpha (TNF-alpha), plasma endothelin-1 (ET-1), nitric oxide (NO) and nitric oxide synthase (NOS) were observed 2 weeks after the ischemia. RESULT: Ligustrazine could significantly reduce serum insulin (P < 0.01), the content of plasma ET-1 (P < 0.01) and serum TNF-alpha (P < 0.01), the activity of brain tissue NO and NOS (P < 0.01). The drug also increased insulin sensitivity indexes (ISI). CONCLUSION: The protective effects of Ligustrazion on IR cerebral ischemia may be related to decreasing ET-1 content in plasma, TNF-alpha content in serum, NO content and NOS activities in tissue.
    [Abstract] [Full Text] [Related] [New Search]