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  • Title: Vaccination with purified Dr Fimbriae reduces mortality associated with chronic urinary tract infection due to Escherichia coli bearing Dr adhesin.
    Author: Goluszko P, Goluszko E, Nowicki B, Nowicki S, Popov V, Wang HQ.
    Journal: Infect Immun; 2005 Jan; 73(1):627-31. PubMed ID: 15618205.
    Abstract:
    The vaccination of C3H/HeJ mice with Escherichia coli Dr fimbrial antigen reduced mortality associated with an experimental urinary tract infection due to a homologous strain bearing Dr adhesin. Immune sera with high titers of anti-Dr antibody inhibited bacterial binding to bladders and kidneys but did not affect the rate of renal colonization.
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