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  • Title: The effect of ionomycin on calcium fluxes in sarcoplasmic reticulum vesicles and liposomes.
    Author: Beeler TJ, Jona I, Martonosi A.
    Journal: J Biol Chem; 1979 Jul 25; 254(14):6229-31. PubMed ID: 156184.
    Abstract:
    Ionomycin, a recently discovered calcium ionophore, inhibits the ATP-dependent active Ca2+ transport of rabbit sarcoplasmic reticulum vesicles at concentrations as low as 10(-8) to 10(-6) M. The effect is due to an increase in the Ca2+ permeability of the membrane which is also observed on liposomes. The inhibition of Ca2+ uptake is accompanied by an increase in the Ca2+-sensitive ATPase activity of sarcoplasmic reticulum vesicles.
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