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Title: Cytotoxic triterpenoid saponins from Symplocos chinensis. Author: Tang M, Shen D, Hu Y, Gao S, Yu S. Journal: J Nat Prod; 2004 Dec; 67(12):1969-74. PubMed ID: 15620235. Abstract: Six new triterpenoid saponins were isolated as methyl or butyl esters from an n-BuOH extract of the roots of Symplocos chinensis. Their structures were established as symplocososides A (1), B (2), C (3), D (4), E (5), and F (6), by extensive 1D and 2D NMR as well as HR-MS analysis and chemical methods. Compounds 1, 3, and 6 were cytotoxic against one or more cell lines, and the derivative from 1 (1d) showed significant selectivities between KB cells and normal cells.[Abstract] [Full Text] [Related] [New Search]