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  • Title: A new orally active antidiabetic vanadyl complex--bis(alpha-furancarboxylato)oxovanadium(IV).
    Author: Xie M, Gao L, Li L, Liu W, Yan S.
    Journal: J Inorg Biochem; 2005 Feb; 99(2):546-51. PubMed ID: 15621288.
    Abstract:
    Bis(alpha-furancarboxylato)oxovanadium(IV)--a new orally active antidiabetic vanadyl complex has been synthesized, characterized, and tested for bioactivity as insulin-enhancing agents. The complex was administered intragastrically to both normal and STZ-diabetic rats for 4 weeks. The results show that the complex at a dose of 10.0 and 20.0 mg V kg(-1), could significantly lower the blood glucose level rats and ameliorated impaired glucose tolerance in STZ-diabetic, but not in normal rats. It was suggested that the complex exerted an antidiabetic effect in STZ-diabetic rats, which maybe was related to increasing the sensitivity to insulin.
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