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  • Title: An investigation of neuronal integrity in severe paediatric traumatic brain injury.
    Author: Parry L, Shores A, Rae C, Kemp A, Waugh MC, Chaseling R, Joy P.
    Journal: Child Neuropsychol; 2004 Dec; 10(4):248-61. PubMed ID: 15621848.
    Abstract:
    Magnetic Resonance Spectroscopy (MRS) and its association with neuropsychological functioning was examined in the chronic injury phase of paediatric traumatic brain injury (TBI). Fifteen children, aged 10-16 years, with severe TBIs were compared with 15 controls, matched for age and gender. The TBI group was found to have significantly lower levels of -acetyl aspartate (NAA) and Choline (Cho) in the right frontal lobe and generally displayed reduced performances on neuropsychological tests. A correlation between metabolites and reaction times was also obtained. Findings indicate a role of proton MRS as a measure of neuronal integrity following severe paediatric TBI and suggest a potential association of MRS with specific neuropsychological impairments.
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