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  • Title: [The antithrombin action of stichopus japonicus acid mucopolysaccharide (Sjamp) is mediated by heparin cofactor II].
    Author: Zhang G.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 1997 Mar; 18(3):126-9. PubMed ID: 15622771.
    Abstract:
    OBJECTIVE: To further evaluate the antithrombin mechanism of stichopus japonicus acid mucopolysaccharide (Sjamp). METHODS: The antithrombin mechanism of Sjamp was checked by assaying its effects on the thrombin activity in normal human pooled plasma,purified human heparin cofactor II (HC II) system and antithrombin III (AT III) system. RESULTS: Sjamp inhibited thrombin activity in the presence of HC II with a second order rate constant of 1.56 x 10(7) m(-1) x min(-1), which was 4.6 times as much as that of AT III. CONCLUSION: Sjamp was similar to dermatan sulfate both in the efficiency and in the mechanism of antithrombin.
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