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  • Title: Gadolinium-enhanced small-animal TOF magnetic resonance angiography.
    Author: Miraux S, Serres S, Thiaudière E, Canioni P, Merle M, Franconi JM.
    Journal: MAGMA; 2004 Dec; 17(3-6):348-52. PubMed ID: 15624104.
    Abstract:
    So far, magnetic resonance angiography (MRA) of rodents has only been performed by using time-of-flight (TOF) MRI techniques. This is because applications of first-passage contrast agents as in humans are hampered by pronounced physiologic differences (blood volume and heart beat rate). Here we describe the use of low-dose Gd-DOTA to enhance the performance of TOF MRA in rat brain. While no improvement in contrast was achieved, the measuring time could be reduced by almost a factor of three. This decrease in total acquisition time has been used to study the impact of a model of ligatured common carotid on the upper part of the blood system of the rat.
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