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  • Title: Biosynthesis of androgens by the sesterterpene pathway via 23,24-dinor-4-cholen-3-one.
    Author: Tait AD.
    Journal: J Steroid Biochem Mol Biol; 1992 Mar; 41(3-8):871-4. PubMed ID: 1562564.
    Abstract:
    Rat testicular and adrenal gland microsomal preparations were incubated with 23,24-dinor-5-cholen-3 beta-ol (Guneribol) a proposed intermediate in the sesterterpene pathway for steroid biosynthesis. Steroids were isolated, purified by thin layer and high-performance liquid chromatography and crystallized to constant specific radioactivity. These preparations converted the substrate to 23,24-dinor-4-cholen-3-one. Radioactive 23,24-dinor-4-cholen-3-one was synthesized and incubated with further tissue preparations and shown to be converted to steroid hormones. These findings suggest that 23,24-dinor-4-cholen-3-one is an intermediate on the sesterterpene pathway for steroidogenesis.
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