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  • Title: [Expression of ferritin receptor on placental microvillous membrane and its role in maternal-fetal iron transport].
    Author: Kong P, Liao Q, Luo Q, Li Z, Fu R, Yang X.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 1997 Nov; 18(11):568-72. PubMed ID: 15625893.
    Abstract:
    OBJECTIVE: In order to investigate the expression of ferritin receptor (FnR) on human placental microvillous membrane in mid-pregnancy and its implication. METHODS: Radioligand binding assay was used, with horse spleen 125I-apo-ferritin as radioligand. RESULTS: The FnR expression in normal placental microvillous membrane in mid-pregnancy was (9.63 +/- 4.72) x 10(12) sites/mg pro, similar to that in normal placental of term delivery,and the dissociation constants (Kd) between them had also no significant difference: Competitive binding assay indicated that the receptor bound basic ferritin with higher affinity than acidic one. CONCLUSIONS: The expression of FnR in mid-pregnancy almost come to mature level; The FnR on placenta might be involved in maternal-fetal iron transport, transfering iron from mother to fetal.
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