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  • Title: [Favourable effect of lacrimal plugs after 3 and 9 months in 20 patients with severe sicca syndrome].
    Author: ter Borg EJ, Bistervels JH, Haanen HC.
    Journal: Ned Tijdschr Geneeskd; 2004 Dec 04; 148(49):2442-5. PubMed ID: 15626310.
    Abstract:
    OBJECTIVE: To describe the results of the insertion of lacrimal plugs in patients with severe symptoms of dry eyes. DESIGN: Prospective descriptive study. METHOD: 20 patients who had severe symptoms of dry eyes despite topical therapy were included. The diagnoses were: 'primary Sjögren's syndrome' (n = 10), 'probably a primary Sjögren's syndrome' (n = 5) and 'secondary Sjögren's syndrome' (n = 5). Following a favourable subjective reaction to resorbable plugs, a non-resorbable silicone plus was inserted bilaterally into the openings of the inferior lacrimal ducts. During follow-up, the effect of treatment was assessed by means of various measurements of function of the lacrimal glands. RESULTS: After 3 and 9 months there was a measurable favourable effect with regard to tear production (Schirmer-test), tear film stability ('tear film break-up time'), the damage to the cornea (Bengal-red-test) and the subjective symptoms of dry eye on a visual analogue scale (VAS). The difference in comparison with the initial values was significant except for the Bengal-red-test after 9 months. There were no complications. In the 5 patients with a basal Schirmer test value of o mm after 5 min, there was no improvement.
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