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  • Title: Spermatogenesis and sperm transit through the epididymis in mammals with emphasis on pigs.
    Author: França LR, Avelar GF, Almeida FF.
    Journal: Theriogenology; 2005 Jan 15; 63(2):300-18. PubMed ID: 15626401.
    Abstract:
    Starting from the period of testis differentiation, the Sertoli cell plays a pivotal role in the development of a functional testis. FSH is the major mitotic factor for Sertoli cells. Because the supporting capacity of Sertoli cells is relatively fixed for each species, their total number per testis, established just before puberty (approximately 4 months in pigs), dictates the potential for sperm production. In contrast to Sertoli cells that are still undifferentiated, mature Leydig cells are already present at birth in pigs. Spermatogenesis lasts from 30 to 75 days in mammals, and this time period is under the control of the germ cell genotype. In boars, each spermatogenic cycle and the entire spermatogenic process lasts 8.6-9.0 and approximately 40 days, respectively. The sperm transit through the epididymis takes approximately 10 days in pigs and this is within the range cited for most mammals. Germ cell loss occurs normally during spermatogenesis, mainly during the spermatogonial and meiotic phases. In pigs, significant germ cell loss also takes place during spermiogenesis. In mammals in general, including pigs, only 2-3 out of a possible 10 spermatozoa are produced from each differentiated type A1 spermatogonium. The high supporting capacity of Sertoli cells and the short duration of the spermatogenic cycle are the main factors responsible for the comparatively high spermatogenic efficiency of pigs.
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