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  • Title: Decreased 5-HT-mediated prolactin release in major depression.
    Author: Anderson IM, Ware CJ, da Roza Davis JM, Cowen PJ.
    Journal: Br J Psychiatry; 1992 Mar; 160():372-8. PubMed ID: 1562864.
    Abstract:
    The prolactin response to intravenous clomipramine, a 5-HT uptake inhibitor, was significantly attenuated in 12 patients with major depression. In contrast, in a further 12 depressed patients, the PRL responses to thyrotropin-releasing hormone, which acts directly on the pituitary to release PRL, were not reduced. These findings suggest that the reduction in 5-HT-mediated PRL release seen in depressed patients is due to an impairment of brain 5-HT function rather than a pituitary abnormality.
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