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  • Title: [In vitro chemosensitivity test for hepatocellular carcinoma using collagen-gel droplet embedded cultures].
    Author: Nakagawa T, Takahashi H, Kamiyama T, Nakanishi K, Takahashi M, Watanabe K, Taguchi K, Tsukahara M, Nakajima H, Kamachi H, Kurauchi N, Kamiyama N, Khor LW, Abumiya K, Matsushita M, Kobayashi H, Todo S.
    Journal: Gan To Kagaku Ryoho; 2004 Dec; 31(13):2145-9. PubMed ID: 15628760.
    Abstract:
    This study evaluated an in vitro assay for chemosensitivity test using a collagen-gel droplet-embedded culture drug sensitivity test (CD-DST) for hepatocellular carcinoma (HCC). In 25 patients with HCC, in vitro chemosensitivity to 5-fluorouracil (5-FU), epirubicin (EPI), and cisplatin (CDDP) was examined by CD-DST, and 5-FU, EPI, and paclitaxel (PTX) were examined in 38 patients with breast cancer. Successful rates of chemosensitive evaluation by CD-DST were 64% for HCC and 79% for breast cancers. Although chemosensitivities of breast cancer were 5-FU 23.1%, EPI 83.3%, and PTX 67.7%, only one HCC sample was sensitive to EPI. Growth rates of HCC for 7 days of culture were significantly lower than those of breast cancers (1.04 vs 3.61). The culture methods for HCC in CD-DST should be improved to estimate accurate results.
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