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  • Title: Enantioselective alkylations of tributyltin enolates catalyzed by Cr(salen)Cl: access to enantiomerically enriched all-carbon quaternary centers.
    Author: Doyle AG, Jacobsen EN.
    Journal: J Am Chem Soc; 2005 Jan 12; 127(1):62-3. PubMed ID: 15631449.
    Abstract:
    The catalytic asymmetric alpha-alkylation of tributyltin enolates with a range of primary alkyl halides is catalyzed by a chiral Cr(salen) complex. The reaction constitutes the first transition-metal-catalyzed system for alpha-alkylation of carbonyl substrates with this important class of electrophiles, providing access to five-, six-, and seven-membered ring ketone products bearing alpha-quaternary stereocenters in high enantioselectivity and synthetically useful yields.
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