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  • Title: [Human serum alcaline phosphatase and ageing].
    Author: Negrão MR, Martins MJ, Ramos E, Barros H, Hipólito-Reis C, Azevedo I.
    Journal: Acta Med Port; 2003; 16(6):395-400. PubMed ID: 15631850.
    Abstract:
    BACKGROUND: In experimental ageing models an inverse relationship between age and alkaline phosphatase activity has been observed. OBJECTIVE: To characterize serum levels of alkaline phosphatase activity in humans according to age and gender. METHODS: Serum alkaline phosphatase was determined in a random sample of 203 community dwellers aged 40 or more years. RESULTS: In men (n=87) total serum alkaline phosphatase markedly increased from the 5th to the 6th decade and then stabilized. For women (n=116) there was a slight increase in total serum alkaline phosphatase from the 5th to the 6th decade, followed by a bend upward after 69 years of age. There was a significant positive correlation between total serum alkaline phosphatase and age for the whole population. CONCLUSIONS: Serum alkaline phosphatase activity appears as a biomarker of age in humans, similarly to what has been described for experimental animal models.
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