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  • Title: 2-(4-alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists.
    Author: Zaragoza F, Stephensen H, Peschke B, Rimvall K.
    Journal: J Med Chem; 2005 Jan 13; 48(1):306-11. PubMed ID: 15634025.
    Abstract:
    With the aim of identifying structurally novel, centrally acting histamine H(3) antagonists, a series of 2-(4-alkylpiperazin-1-yl)quinolines was prepared. Systematic variation of the substituents led to highly potent histamine H(3) antagonists with low polar surface area and appropriate log P for blood-brain barrier penetration.
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