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  • Title: Evaluation of proliferating markers Ki-67, PCNA in gastric cancers.
    Author: Czyzewska J, Guzińska-Ustymowicz K, Lebelt A, Zalewski B, Kemona A.
    Journal: Rocz Akad Med Bialymst; 2004; 49 Suppl 1():64-6. PubMed ID: 15638377.
    Abstract:
    Tumours from 45 patients with advanced gastric cancer were assessed by immunohistochemistry. Tissue sections were fixed in 10% buffered formaldehyde solution, embedded in paraffin and stained immunohistochemically with anti-human Ki-67 and PCNA antibodies. No correlation was found between Ki-67, PCNA protein expression, the age of patients and the localization of tumour. A significant, positive association was observed between the expression of Ki-67, PCNA and tumour differentiation and Lauren's classification. Also a strong correlation was found between lymph node involvement and the expression of Ki-67 protein. These data suggest that the expression of Ki-67, PCNA proteins were closely connected with the high grade of tumour malignancy.
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